In an interview for unWIRED TV, voice actor for everybody's favourite Resident Evil villain Albert Wesker, D.C. Douglas, was able to confirm that Wesker does indeed play a major role in the upcoming Darkside Chronicles game for Wii.
Details regarding Wesker's role in Darkside Chronicles is currently unknown but it's possible Wesker will feature in a number of flashbacks during the first two playable "episodes" and almost certainly will return to hog the spotlight during the Code Veronica "re-imagining" episode.
D.C. Douglas also mentioned something during the interview which I found quite interesting: apparently he did a voice over for Wesker in what he called a prequel; only a short piece of dialogue but it's definitely something. Obviously, this has me eager to learn more, will we be seeing another Resident Evil prequel further down the line? Perhaps a prequel to Resident Evil Zero (0)? Perhaps Resident Evil -1? Are we going to go into the minuses? I jest but I'm definitely eager to learn more about this rumoured prequel.